Anna Kendrick co-stars in “50/50,” which opens Sept. 30. Formerly titled “I’m With Cancer,” it’s a dramatic comedy about a young guy (Joseph Gordon Levitt) who learns he has it and the reaction of his friends, lovers and family. And the reaction of a naive young therapist, played by Kendrick.

She won great acclaim and an Oscar nomination for her turn in “Up in the Air,” playing a corporate layoff specialist in training. But her first claim to screen fame was being part of the cast of “Twilight,” a saga she just finished filming.

“You know, when we finished, it felt celebratory. It didn’t feel maudlin. We’d made it through these crazy movies without losing any fingers or toes to frostbite. It felt like Mission: Accomplished.”

On one of her dreamy co-stars, who has a movie, “Abduction,” in theaters Friday:” Taylor Lautner is a more responsible adult than anybody I’ve ever met. At one point, during Oscar season, he saw me at a party with a friend, both of us older than Taylor. And as he leaves, he says ‘You kids have fun tonight.’ I was like, ‘You need to be president, someday, sir.’ I marvel at his maturity.”